Objective: Assessing in adolescents if a higher dose of physical activity generates higher profits in cardiovascular risk factors such as blood pressure (BP), body mass index (BMI) and waist circumference (WC). Methods: In the present observational, analytical, cross-sectional study, 101 adolescents of both sexes from two institutions of secondary education, each of which, in accordance with the course syllabus in physical education had different doses of physical activity were compared (FA). In an institution found that the program had a low dose (LD) and the other, a high dose (HD) of FA. PA, BMI and WC were measured. Results: There was no significant difference in the mean BP between the groups studied, however in the group with LD of FA there was a higher prevalence of systolic high BP (SBP) (29% vs 10%, p <0.014). Adolescents with LD of FA showed higher BMI (22.56 vs. 20.87 kg/m2 SC, p <0.007) and CA (77.61 vs. 73.54 cm, p <0.009), and a significant association with higher frequency of overweight and obesity (15.7% vs 2%, p = 0.045) than those with HD of FA. In the correlation analysis with the total participants, we observed that the diastolic BP (DBP) had a direct and positive correlation with weight, BMI and CA. In contrast, SBP did not correlate with any of these variables. Conclusions: We conclude that in adolescents, a HD of FA is associated with greater beneficial effects on cardiovascular risk factors as were: lower prevalence of high SBP, lower BMI and WC. Therefore, it is considered that teens should practice a vigorous aerobic physical activity with a higher dose than recommended so far.