The development of new materials for bone regeneration constitutes a challenge for biomedical sciences, especially when it is desirable to design synthetic materials that simulate the most the composition of natural bone. In this work biocompatibility of carbonated apatite (CAp) was evaluated. CAp was prepared through mechano-chemical mixing, compression and sintered at high temperature (referred as dry synthesis) of powdered precursors. This ceramic was then used as a substrate for the culture of porcine osteogeprogenitors. Cells were obtained from the bone marrow of adult porcine just after