Objectives. Tumors of the central nervous system are one of the pathologies with big mobility and mortality in the population. In Colombia there are only few studies that review the characteristics of these lesions. The objective of this research was to study the demographic and histopathological characteristics of patients with brain tumors who were treated in the Clinica el Bosque, Bogota. Materials and Methods. We reviewed the pathological studies of those patients with tumors of the central nervous system who were done in the Clinica el Bosque between August 1, 1978 and August 31, 2008. Results. 212 pathological studies were found from patients who accomplished the inclusion criteria. 58.5% of the patients were female. Glioma was the most frequent tumor found in 71 cases of the 212. Conclusion. In these series, central nervous system tumors present mostly in adults, the most productive stage of life. These series of central nervous system tumors is one of the first studies that review epidemiological aspects in Colombia.