Methods: Caries status was assessed in 85 2-to-25-year-old subjects with cleft lip palate using ICDAS-visual criteria and scoring filled/missing due-to-caries surfaces. Results: All participants had ≥1 caries lesions (ICDAS-criteria) in the primary dentition and ≥5 in the mixed and permanent dentition. The mean dmf-s/DMF-S was very similar in the three groups with significantly higher values when non cavitated lesions were added. The most affected teeth with caries lesions were, in primary dentition, the second lower-left-primary molar; the first lower left permanent molar in mixed dentition; and the second lower left permanent molar in permanent dentition. Regarding the anterior upper teeth, in the primary dentition group, the lateral right upper incisor was the fourth most affected; in the mixed dentition group the left central upper incisor was the third; and in the permanent dentition group the right upper canine was the fourth most affected. Conclusions: The results showed a high caries experience, with an apparently natural teeth distribution, not being the anterior upper teeth the most affected, as one could expect.