El proposito de esta investigacion fue establecer la frecuencia de trastornos neuropsiquiatricos en estudiantes universitarios con bajo rendimiento academico de la Universidad San Buenaventura Medellin. Se calculo una muestra aleatoria de 39 sujetos con problemas academicos de diferentes carreras, lo cual correspondio al 13 % de la poblacion, para detectar trastornos cuya frecuencia fuera superior al 2%, con un nivel de confianza del 95% y un poder del 80%. Se utilizo una entrevista estructurada neuropsiquiatrica para adultos (MINI-Plus). Los trastornos que se presentaron con mas frecuencia fueron depresion mayor con riesgo suicida (10.3 %) y riesgo suicidio (10.2 %). El 61.5% de la muestra no reunio criterios para diagnostico de psicopatologia. The purpose of this research was to establish the frequency of neuropsychiatric disorders in college students with poor academic achievement of San Buenaventura University in Medellin- Colombia. From a population of 300 students, a random sample of 39 subjects with academic difficulties from different undergraduate programs which corresponds to 13% of the population was taken, in order to detect disorders with a frequency upper than 2%, a confidence level of 95 % and a power of 80 %. A neuropsychiatric structured interview for adults (Mini-PLUS) was used. 61.5% did not show any neuropsychiatric diagnosis; however, 10.3% presented major depression criteria, and 10.3% suicide risk. Keywords: Psychopathology, Lower Academic Performance, Academic Failure, Academic Achievement, University Students, College students, Diagnosis, Clinical Interview, Structured Clinical Interview.