This work was carried out in Palmitas rural area of the Municipality of Medellin, located between 1.400 and 3.100 m.a.s.I., with temperatures between 10C° and 17 C° and a average precipitation of 2.400 mm. / year. In this area an intensive production of vegetables exists, with an use and intensive handling of agrochemestries. This situation generates problems in the economic development, environment and human health of the region inhabitants. The present research showed that a widespread ignorance exists on the agrochemestries manipulation; with empiric preparations of mixtures, in the use of not recommended doses and frequencies; which is agravated by the remiss attention to the technical recommendations, such as, label information, residuals disposition and containers, type of mixtures, and the use of elements for personal protection. This situation is increased by the ignorance on symptoms and handling of intoxications, for the high level of illiteracy, added to the indefiniteness of the basic information about the products. Equally it was found out that the participation of women and children in the processes of agrochemestries application is exposing them to health problems. This problem is intimately related with cultural, social, economic and technical factors. It was also stated that the peasants of Palm itas use a wide range of toxic products, showing a high preference for the fungicidal Maneb (Carbamato) and forthe insecticide Dimetoato (Organofosforado). Products associated to the inhibition ofthe colinesterasa.