Objetive: To determine the factors associated with breast cancer in women diagnosed with the disease, attended in the health institutions of the Municipality of Popayan Cauca during the years 2014-2017. Methodology: To determine the associated factors, family history, reproductive characteristics and lifestyles were taken into account in the risk of developing breast cancer. Cases (116) diagnosed for the first time and with histological confirmation for years 2014 were studied. 2017, residents in the municipality of Popayan and over 18 years of age. The controls were selected matched by age and with a diagnosis of negative mammography. The information was obtained through an interview and the analysis was carried out using the statistical package SPSS. Results: The stratum that predominated in the cases was 1 (35.3%), controls with stratum 2 (30.2%); Average income of cases was <1 (SMLV) (56%), controls between 3 to 4 SMLV (36.2%); Family history of cancer increases to 3.5 times the strength of association to having breast cancer (P <0.001). ). Age of menarche, Regularity of the menstrual cycle, Number of pregnancies and fetal deaths had statistical significance (P <0.05) ) in both groups. Conclusions: The age at diagnosis of cancer, ethnicity, educational level and affiliation regime were statistically significant among the study groups; being in a stratum less than or equal to 2 presents a greater risk association than living in a higher stratum zone.