Introduction – Pancreatoduodenectomy (PD) is a highly complex procedure that requires high levels of training and excellence in surgical technique. With a mortality close to 25% at its inception, technological advances and the appearance of high-volume centers allowed for an improvement in morbidity and mortality associated with surgery. Objective – To describe the morbidity and mortality and outcomes associated with Whipple surgery (pancreaticoduodenectomy) as an integral management of pancreatic cancer and other periampullary tumors in a population of patients treated in a high-volume center in Bogotá D.C., Colombia. Materials and Methods – A retrospective descriptive study of 131 pancreaticoduodenectomies performed by a surgeon (JCS) between 2014 and 2019 together with the description of the management established by an interdisciplinary group of Hepatobiliary and Pancreatic Surgery. Data are retrospectively reviewed and patient demographics as well as clinical outcomes and surgical and oncological outcomes are described. Results – The most frequent indication for surgery was pancreatic ductal adenocarcinoma with a histopathological diagnosis in 44% of patients. The age range of the patients was between 20 and 86 with a mean age of 65 years. The most frequent complications were postpancreatectomy hemorrhage (21%) and pancreatic fistula (8%). A biochemical leak rate of 21% was evidenced. Surgical mortality of 14% and patients had a 2-year survival of 46%. Conclusions – The development of multidisciplinary groups and the optimization of the surgical technique allow obtaining comparable results with international registries in a high-volume center in the city of Bogotá D.C., Colombia.