INTRODUCTION: Transjugular intrahepatic portosystemic shunt (TIPS) is a therapeutic procedure performed in patients with severe Portal Hypertension who have presented ascites or Upper gastrointestinal bleeding secondary to esophageal varices refractory to conventional treatments. It consists in the creation of a shunt between the portal vein with a suprahepatic vein, in order to reduce the pressure of the portal system and derive towards the systemic venous system. In the available medical literature, the development of encephalopathy has been described among the most frequent complications, however, a prognostic variable for its presentation has not been established so far. Thus, the need to identify implicit variables before, during and after the therapeutic procedure (TIPS), especially the post-procedure portosystemic gradient, are related to the development of neurological complications. OBJECTIVE: Explore the demographic and clinical variables related to the presence / absence of hepatic encephalopathy and evaluate the relationship between the post-TIPS portosystemic gradient and the development of encephalopathy. METHODS: A retrospective cohort was presented, by reviewing all cases. Interventions for TIPS from 2007 to 2016 in the Fundación Cardioinfantil, for a bivariate analysis between the presence / absence of hepatic encephalopathy and multiple demographic variables (age, sex) and clinics (gradient post-tips, CHILD classification, MELD classification) , number of previous bleedings, previous use of propranolol and stent size). RESULTS: In the bivariate analysis, no differences were found clinically or statistically in the development of hepatic encephalopathy and independent variables such as age, MELD score, CHILD score, the number of gastrointestinal hemorrhage and the portosystemic gradient and others. CONCLUSION: The information collected in the study shows that the development of hepatic post-TIPS encephalopathy in the studied patient cohort did not present a statistically significant relationship with both demographic and intrinsic variables of the procedure; This result carried out in the reference institution is largely influenced by the limitations of the study in obtaining data since the need to exclude some patients was presented. However, it is important to take into account the findings described in the literature regarding the relationship of demographic and clinical aspects as determinants in the development of complications such as hepatic encephalopathy.