Introduction: Liver transplantation is the therapy of choice for patients with end-stage liver disease because it improves their life expectancy and quality of life, according to studies conducted in other countries. In the Fundación Cardioinfantil – Instituto de Cardiología (FCI-IC), 332 liver transplants have been performed since 2005, but the survival and prognostic factors of the patients undergoing surgery is not known. Objective: To estimate the survival after 1, 3 and 5 years of the transplantation and to identify the main prognostic factor of patients who underwent liver transplantation between 2005 and 2013 in the FCI-IC. Method: Observational, retrospective study, based on the review of medical records of adult patients who underwent liver transplantation in the period 2005-2013 in the FCI-IC. Results: One-year survival was 90.91% (95% CI 86.40-93.98), at 3 years 83.64% (95% CI 77.89-88.01) and 5 years of 79.18% (95% CI 72.54-84.39). The main prognostic factors were a history of ascites (HR 2.449, IC 1252-4792), donor age (HR 1.040, IC 1009-1071) and recipient age (HR 1.037, IC 1014-1060). Increased survival was found in patients with alcoholic cirrhosis (HR 0.099, IC 0021-0467). Conclusions: The study showed a greater survival than that reported in studies conducted in the United States (67.4-73.0% at 5 years), Spain (73.3% at 3 years) and Chile (80.0% survival 5 years). It should be noted that these studies included larger patient series.