SARS-CoV-2 infection has been associated with multiple neurological manifestations.One such manifestation, which has been described since the early stages of the COVID-19pandemic and is relevant for current neurological practice, is Guillain-Barré syndrome (GBS).The literature describes neurotoxic mechanisms of the virus itself and the possible pathways bywhich it may affect the peripheral nerves in experimental studies; however, we still lackinformation on the mechanisms causing the immune response that gives rise to GBS in thecontext of SARS-CoV-2 infection. Colombia is one of the Latin American countries worst affectedby the pandemic, with the third-highest number of cases in the region; thus, it is essential torecognise GBS, as this potential postinfectious complication may severely compromise thepatient's functional status in the absence of timely diagnosis and treatment. We present a series of 12 cases of GBS associated with SARS-CoV-2 infection from hospitals in 4 different Colombian cities and describe the clinical presentation, laboratory and electrophysiological study findings,and treatment.