Introduction A systematic literature review and meta-analysis was performed to determine the utility in terms of reducing the intensity and the prevention of post-dural headache of intravenous corticosteroids. Materials and methods Systematic review and meta-analysis, two reviewers selected and analyzed articles defined in terms of input, extracted general characteristics of the included studies, described the main findings and summarized their results. Heterogeneity by I2 and Tau2 coefficient was analyzed, the magnitude of effect was analyzed in the coefficient Z, all statistical assumed a significance level of 95%, in tables and figures (control bias and Forrest Plot) Results 75 references were selected, 33 identified in the search and 48 Snowball method; Six agreed with the eligibility criteria; 69 were excluded for not meeting the inclusion criteria; masking aspect of increased risk of bias (intermediate); All in all it was good control of risk of bias among the included studies. The results show low heterogeneity for intervention with steroids in the treatment of post-dural headache; wide heterogeneity and void for preventing post-dural headache. Conclusions The use of hydrocortisone or methylprednisolone in reducing the intensity of the post-dural headache is recommended. You do not have evidence of dexamethasone in preventing post-dural headache. It requires additional studies with other pharmacological interventions on the plausibility of the condition (post-dural headache) could prevent or reduce its occurrence