Diabetes Mellitus is considered a public health problem, which, when is not controlled, can lead to micro and macrovascular complications, which have several negative impacts in the patient life. Glycated hemoglobin is one of the most useful clinical parameters to evaluate the glucose regulation of the patient. A level higher than 8.0% of glycated hemoglobin is considered poorly controlled. The type of management care program that the patient is affiliated with always modifies this parameter. Methodology: A retrospective dynamic cohort study was conducted in a group of patients with uncontrolled type II diabetes mellitus who were affiliated with a private “IPS” in Cartagena city, between February 2016 to February 2017. The aim of this study was to estimate, the impact of the management care program on the glycated hemoglobin levels, cholesterol levels (LDL), and variation in glomerular filtration rate. Results: 259 patients were included in this study and it was concluded that the management care program had a positive impact on a large part of the treated population, reaching a statistically significant reduction in glycated hemoglobin levels (p=0,000) and increase in the glomerular filtration rate (p=001) with the consequent recovery of the patient's clinical condition. These results were affected by the amount of time the patients were affiliated in the program, the frequency of contact with the program and by the comorbidities present.