Background: Quantification of coronary artery calcium has been previously studied as a predictor of coronary events; however, the association between this parameter and the appearance of stenotic coronary lesions remains uncertain. Methods: We reviewed the multidetector coronary angiography studies of 207 asymptomatic patients as well as the quantification of coronary artery calcium performed by Agatston method. We tested for statistical association between these two using chi-squared and Pearson tests. Results: Our tests showed a positive and significant association between quantification of coronary artery calcium and the appearance of stenotic lesions. This association was independent of anatomic localization. Discussion: In asymptomatic patients, quantification of coronary artery calcium and the appearance of stenotic lesions are correlated. This association might be relevant in the design or implementation of screening methods for coronary disease.