Introduction: Infections are one of the most frequent reasons for admission to the intensive care unit. In turn, infections associated with the health care of resistant germs can occur within the spectrum of additional conditions as a problem in patients with prolonged stays. The identification of risk factors for its presentation is important Objective: To identify factors associated with mortality in patients admitted to the Intensive Care Unit at the University Hospital of La Samaritana and had infections due to Gram-negative bacteria producing KPCtype carbapenemase. Materials and methods: A type of retrospective, analytical, case-control study was conducted between January 2013 and December 2016, where 47 isolates of KPC-producing germs (Klebsiella pneumoniae carbapenemasa) extracted from the reports of typified cultures consigned in the clinical histories were analyzed Results: The average age was 58 years and a higher percentage in men. 19% of patients had autoimmunity and 66% presented with septic shock. 36% of isolates in orotracheal secretion with more frequent germ Klebsiella pneumoniae (72%). Gram-negative mortality is 45% and the risk factors found were CSF isolation OR 18.905 P 0.046 (CI 1.048 - 340.971), catheter-associated bacteremia OR 10.1 P 0.021 (IC 1.408 - 72.619) and KPC OR resistance pattern 32 P 0.015 (IC 1,975 - 529,480). Conclusions: The most important risk factors found to have an isolation by KPC are catheter-associated bacteremia and cerebrospinal fluid isolations. Studies are missing to specify the most common risk factors associated with infections caused by this type of carbapenemasa.