Introduction: mobile technologies, due to their easy use and widespread dissemination, have become an important tool in public health, allowing early identification of outbreaks as a complement to traditional surveillance. The objective was to analyze the data of a mobile application to detect diseases of interest in public health related to the visit of Pope Francis to Colombia. Methods: participatory surveillance is applied through the Guardianes de la Salud mobile application, implemented for Colombia on Android devices, adapted from the development of Proepi and the Ministry of Health of Brazil for the Rio de Janeiro 2014 Olympic Games. It was questioned about 20 symptoms That allows to detect respiratory, febrile, gastrointestinal, exanthemic and icteric syndromes, related to events of interest in public health. He asked about travel history and contact with other patients. The data is monitored during the days of the Pope's visit to the country and up to seven days later. Results: 936 reports were received, 60.2% (283) were from Bogotá, 23.0% (215) from the department of Meta and 22.0% (206) from Antioquia, there are also reports from other countries such as Brazil ( 21), the United States, Panama (3), Chile (2) and Costa Rica (1). 55.1% (516) were women, the average age was 39 years (D.E. 12.3). 8.5% (80) reported their health status, being the main symptom of headache in 41.3% (33), followed by discomfort 40.0% (32) and nasal congestion 38.8% ( 31). 53.7% (43) of the reports are associated with some of the prioritized syndromes, the main one being February in 22 cases and gastrointestinal in 11. Conclusion: no conglomerates of important public health cases were detected. The tool allowed to involve the general public in the notification of their health status. It is necessary to promote the use of this application or the measure that increases the number of users, as well as the sensitivity provided by the expanded monitoring of participatory surveillance.