Facial lipoatrophy is one of the side effects that most frequently occurs and affects the quality of life of patients with HIV receiving antiretroviral treatment. Methods: Cross-sectional observational study involving 126 subjects, who were surveyed semi-structured to determine how the patient perceives that it affects facial lipoatrophy in areas affective, social, labor and occupational evaluate the perception of body image ; characterize sociodemographically; determine the prevalence of facial lipoatrophy and whether there are differences in perception of body image according to sociodemographic. Results: The prevalence of facial lipoatrophy was 57.1%. The degree of satisfaction with physical appearance had an average of 5.01 ± 2.69. The 88.7% and 80.3% of patients tested felt sadness and frustration with their appearance respectively. The 53.5% and 42.9% reported fewer employment and educational opportunities. Sexual orientation was most frequently reported homosexuality. There were no statistically significant differences between the degree of satisfaction with sociodemographic appearance except in patients who received psychological support. Conclusion: First nationwide study that evaluates the impact of facial lipoatrophy in patients with HIV and antiretroviral treatment. Although the presence of facial lipoatrophy, on everyday is not statistically significant if there is momentous because significant percentages of emotions and psychological disorders that directly affect these subject areas in affective, social, labor and occupational. It is necessary to conduct more studies to obtain further evidence.