Introduction: During the current COVID-19 pandemic, knowing the diagnoses of the patient's disease is essential to optimize and timely manage infected patients and their comorbidities in order to avoid higher mortality. The objective of the study is to analyze associated disease comorbidities as risk factors for mortality from COVID-19. Methodology: A overview of systematic reviews was carried out using PubMed, SCOPUS, Cochrane and Google Scholar databases as search tools from January 2020 to November 2021, with the date of the last search November 30. 2021. Systematic review studies on risk factors and mortality in patients infected with COVID-19 were selected. Two reviewers extracted the analyzed data with the Rayyan® tool, assessed the methodological quality. A summary of qualitative systematic reviews was carried out according to the Cochrane criteria. Results: Six systematic review studies were reviewed, including 96,341 patients from different countries around the world. In this review, a descriptive analysis between different variables and mortality rates was performed. These variables included related comorbidities such as smoking, diabetes mellitus, high blood pressure, chronic kidney disease, respiratory disease and cancer, all of which were significant. Conclusions: In the descriptive analysis, an association was found with the variables obesity, hypertension, DM, respiratory disease, malignancy, smoking, CKD, CVD.