Background The evidence of use vasopressin is limited in the pediatric population and therefore this study seeks to evaluate its effect on mean arterial pressure, hospital stay, mortality and tissue perfusion in children with refractory septic shock in the referral Pediatric Intensive Care Unit. Materials and methods Observational, retrospective cohort study in children from 1 month to 18 years old with refractory septic shock. 129 infants are included, of which 70 received noradrenaline alone, and 59 received vasopressinnoradrenaline. As