The eastern forelands of the South American Andes thrust belt contain prolific petroleum systems. In Colombia, this foreland, called the Llanos Basin of Colombia (LBC), is currently subsiding, and the maturation of the source rocks, as the migration of the hydrocarbon that started at the Miocene times, is ongoing. Although the success ratio of the exploration companies in this area is very high, the exploration and production are complicated by the presence of a high water/oil ratio in the produced fluids.