Crop domestication has been aptly considered by Jack Harlan (1992) as bringing wild-growing plants into the human household. This deep alteration of ecological relationships between the domestication-candidate and other biota in the novel and very different cultivated ecosystem – the domus – was eventually reflected in marked morpho-physiological and, hence, genetic differences between the domesticate and its wild progenitor. These differences, also labeled the domestication syndrome, concern primarily the organs and traits affected by human selection. They are often discrete and continuing, with a few loss-of-function ones (such as the lack of natural seed dispersal mechanisms). The end-point of this continuum (Pickersgill 2007) is full dependence of the domesticate on human activities for growth, reproduction, and long-term conservation.