The COV19 - Impact on Quality of Life (COV19-QoL) has been used as a measure of the perceived impact of COVID-19 on quality of life; however, little is known about its cross-cultural utility. The present study evaluated the measurement invariance of COV19-QoL in adult samples (N = 1034; Mage = 35.7 years; SD = 13.3 years; 68.3% women) from four South America countries (Ecuador, Colombia, Per? y Bolivia). The COV19-QoL unidimensional model fit indices were adequate in all the countries (CFI = 1.00, TLI = 0.99, SRMR = 0.02, RMSEA = 0.10). Both the alpha and omega indices had acceptable values ranging from 0.91 to 0.94 in all countries. Factorial invariance was evaluated using the alignment method, and invariance was obtained for the factorial weights (R2 = 1.00) and intercepts (R2 = 1.00), admitting the approximate invariance of COV19-QoL. The COV19-QoL can be recommended to meaningfully compare relationships between variables between groups and to compare latent means in four South American populations.