Exposure to violence is one of the most common adverse effects. In recent years, there has been a particular interest in understanding the link between exposure to violence and the perpetration of other forms of violence, such as child-to-parent violence, a complex family problem that severely affects the relationships between family members. Objective: We aimed to examine the mediating role of instrumental and reactive reasons in the relationship between exposure to violence and child-to-parent violence in different contexts. To fulfill this objective, it was necessary to analyze the evidence of validity and psychometric properties of the Violence Exposure Scale with Colombian adolescents. Methods: A total of 981 Colombian adolescents between aged 12 and 18 years participated. The participants responded to two psychometric scales: one on exposure to violence and the other on child-to-parent violence. Results: The Violence Exposure Scale presented an excellent psychometric model and evidence of adequate validity and reliability. Girls reported greater exposure to violence at home and boys reported greater exposure to violence at school and on the street. In general, older adolescents reported greater exposure to domestic violence. Instrumental and reactive reasons were significant predictors in the perpetuation of child-to-parent violence, with victimization in the home being the best predictor and reactive reasons the strongest mediating variables. Conclusions: Exposure to violence in the home is a key predictor; however, the co-occurrence of violence in other settings plays an important role in polyvictimization and predicting future violent behavior.