This cross-sectional study aimed to investigate the factors that affect the quality of life of drivers. Data were collected from 62 drivers working on long-haul transport who completed the short form-12 (SF-12), perceived stress scale (PSS), Nordic musculoskeletal questionnaire (NMQ), work role function questionnaire-27 (WRFQ-27) and visual analog scale (VAS). According to the regression analysis, the physical health-related quality of life of drivers was predicted by age, marital status, unemployment, having an extra job, pain and stress (R2 = 0,663). Due to intense working conditions, employers need to take various precautions against drivers' stress, fatigue, pain and job requirements. In addition, it is important for these people to be directed to occupational therapy services in order to increase their occupational balance and quality of life.