<title>Abstract</title> Previous scholars have recognized the importance of proposals regarding vaccination-related interventions that can help address various factors that increase the population’s reluctance to receive vaccinations with the goal of promoting coverage and conscious decision-making in this context. This article presents the results of the VACtívate strategy, a psychoeducational intervention that was implemented in 20 cities in Colombia with the aim of promoting knowledge and actions in support of a comprehensive view of vaccination. On the basis of the findings of the Adervax project⁷, VACtívate consisted of a short course that included four modules (i.e., Education in Vaccines, Decision-Making in Vaccination, My Role as an Influential Agent in Vaccination and Integration of Proposals into Public Health) and targeted health personnel, social leaders, health authorities and journalists/social communicators. The qualitative results were systematized with the assistance of ATLAS.ti software, and relevant knowledge was evaluated both before and after the intervention. VACtívate was associated with statistically significant changes before and after the application of knowledge (<italic>p =</italic> .0007). Similarly, concepts pertaining to vaccination could be consolidated and applied to various practices involving the population, in which context a novel perspective on decision-making, the importance of leadership and the construction of proposals in public health was identified. The results of this research reveal that the work conducted alongside territorial entities operating in the health sector in each municipality can facilitate the implementation of relevant health proposals. In terms of recommendations for future research, intervention strategies targeting vaccination should be based on evidence obtained from previous diagnoses as well as the construction of knowledge through the participation of all members of the relevant populations and recognition of their needs. It is crucial to ensure that participation and the construction of the topic involve collaboration among all relevant parties, which can enable us to develop more comprehensive approaches that are not limited to an informative role. Increased involvement on the part of social communicators should be considered in this context, thus guaranteeing that the development of the strategies implemented in this regard can be more effective.