ABSTRACT The concept of the third mission of universities emphasizes the importance of universities actively collaborating with industry and society to promote knowledge transfer, innovation, and regional development. This article presents a systematic literature review conducted in the Scopus database, analyzing 67 papers to trace the evolution of research on this topic. Using tools such as VOSviewer and Bibliometrix for data visualization, a growing interest in areas such as the triple helix, technology transfer, and entrepreneurial universities was identified, while new areas of focus, including information management and the knowledge economy, are emerging. The methodology employed combines PRISMA method standards, bibliometric analysis, and systematic review. The results underscore the need to integrate the third mission into university strategies globally to advance sustainable development.