This research investigates the effectiveness of four metaheuristic algorithms, the Population-Based Genetic Algorithm, Particle Swarm Optimization, JAYA, and Generalized Normal Distribution Optimizer, for managing the energy production of wind-based distributed generators (DGs). The aim is to reduce operational costs in a 33-node microgrid (MG) operating under both connected and isolated configurations. The study seeks to identify the most efficient algorithm for minimizing operational expenses in distributed generation systems, specifically in terms of energy production and purchasing costs, as well as the maintenance costs of DGs. Due to limited statistical validation and unrealistic operational constraints in previous studies, we propose a novel framework that offers a robust, reproducible solution for optimizing the management of wind-based distributed generators in microgrids. Through 100 independent trials for each algorithm and configuration, rigorous statistical analyses are conducted, including ANOVA and Tukey’s post hoc test, to assess performance consistency and the significance of cost reduction outcomes across algorithms. The results indicate that the PGA demonstrates superior cost efficiency and stability, particularly in the connected MG configuration.