Introduction: COVID-19 disease has a wide spectrum of manifestations, going from asymptomatic to severe cases, where respiratory failure and acute respiratory distress syndrome feature a high mortality rate. Among the extrapulmonary manifestations, hematologic manifestations, including autoimmune hemolytic anemias, are becoming of great interest. Case presentation: a patient with severe COVID-19 disease and documented cold antibody autoimmune hemolytic anemia. Discussion: is focused on the literature found since the COVID-19 pandemic was declared and its relationship with said hematologic disorder. Conclusions: the importance of this report lies in recognizing the relationship between these two entities to provide timely treatment.