The Skinner box is a tool the behavioral psychology laboratory has at Universidad CatólicaPopular del Risaralda. It is used by students and researchers during their practices onrodents in order to analyze their behavior and explain some human conducts. This paperpresents the simulation for one of the experiments, using the Proteus software from a testcalled the ratio test sets; this simulation is part of the process being developed in the researchproject Evidence Automation on Operant Conditioning (Skinner box) at UCPR in order todevelop a prototype for the control of laboratory instruments.