Objective The aim of this study is to determine the effects of self-management interventions in adults with Acute Coronary Syndrome. Methods Systematic review and meta-analysis. The Prisma checklist was used. Embase via Ovid, Lilacs, Medline via PubMed and Central were searched for randomized controlled trials. The Cochrane collaboration guidelines were followed and reported using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (Prisma) statement. The Revman program was used to consolidate the data. A sensiti- vity analysis was carried out. Results A total of 17 randomized controlled trials met eligibility criteria. The results showed that self-management interventions did not significantly enhance patients’ com- pliance with medication OR=1.32 (95% CI 0.66-2.64), lifestyle changes OR=1.08 (95% CI 0.55-2.15) and modification of clinical variables MD=-1.77 (95% CI -2.96 6.50). Conclusion This review suggests that there are no statistically significant differences between self-management interventions and the usual care given to patients with Acute Coronary Syndrome Compliance with Pharmacological Treatment, lifestyle changes and Changes in Clinical Variables.