Abstract Researchers are addressing challenges transitioning from natural gas to hydrogen, particularly in transportation and compression. This study evaluates the performance of a gas turbine compression system that compresses gaseous fuel, focusing on a SolarTurbines TAURUS 60 gas turbine with an output power of 5740 kW and nominal efficiency of 32 %. The 12-stage Solar C33 compressor achieves a maximum total head of 257 kJ/kg and an isentropic efficiency above 80%. Energetic, exergetic, and exergoeconomic analyses were conducted for various hydrogen/natural gas mixtures. The results indicate a reduction in CO2 emissions of 187.5 kg per ton of fuel processed with every 10% increase in hydrogen content. Furthermore, setting the oxygen percentage in turbine exhaust gases at 14% and increasing the hydrogen content by 50% reduced the air and fuel requirements by approximately 15%. The Turbine-Air Compressor Work Ratio decreased with higher hydrogen fractions, enhancing the compression train energy efficiency from 6.28% to 27.21%. Exergy analysis revealed decreased total exergy destruction and increased exergetic efficiencies with increasing hydrogen percentage, except for the combustion chamber and gas turbine. Exergoeconomic analysis indicated an increase in the specific cost of gas with higher hydrogen fractions, reaching $20.56/Gj for 100% hydrogen.