Abstract Background Inflammatory bowel disease (IBD) impairs patients’ quality of life, and hence, there is increased awareness of patient-reported outcomes (PRO). Intestinal ultrasound (IUS) is becoming increasingly important as a noninvasive patient monitoring strategy. However, no data exist on the concordance between PRO and IUS findings. Therefore, we investigated the association between PRO, assessed by the IBD Questionnaire-32 (IBDQ-32), and IUS parameters. Methods This prospective study recruited patients with IBD who underwent IUS assessment, while subsequently, an IBDQ-32 was recorded. The IUS parameters captured were bowel wall thickening (BWT), colour doppler sign using the modified Limberg score and color wall flow (CWF) absent or present, also, presence of lymphadenopathies, and mesenteric fat hypertrophy. We performed uni- and bivariate analysis. A p-value <0.05 was considered significant. Results A total of 55 patients were included [37 with ulcerative colitis (UC); 18 with Crohn’s disease (CD)]. In UC, we observed a significant association between IBDQ-32 and BWT (P=0.049), CWF (P=0.02) (Figure 2). and mesenteric fat hypertrophy (P=0.040) respectively. Exploring the dimensions of the IBDQ-32, there was a statistically significant association between the dimension of gastrointestinal symptoms (P= 0.002) and systemic symptoms (P=0.003) with CWF, as well a with BWT respectively (P= 0.013). No association between IUS features and emotional and social dimensions was observed. The validated MUC score (cutoff 6.2) associated significantly with IBDQ-32 (P=0.010) (Figure 1). No associations were observed in patients with CD. Conclusion The quality of life assessed by IBDQ-32 is associated with intestinal ultrasound parameters that reflect disease activity in UC.