Background and Aims Recent randomized controlled trials demonstrated the benefit of thrombectomy for large vessel occlusion in acute ischemic stroke patients. Real‐world data aid in assessing reproducibility of outcomes outside of clinical trials in various countries. We have designed and implemented a national registry in Turkiye. We present the design, progress, and initial data from the Turkish National Thrombectomy Registry. Methods Patients aged ≥18 years who underwent thrombectomy for acute ischemic stroke were registered. The key items on the data collection form were divided into general stroke demographics and thrombectomy related sections. The main outcomes of effectiveness are post procedure angiographic recanalization graded using modified Thrombolysis in Cerebral Infarction grade and functional independence (modified Rankin Scale score, 0‐2) at 3 months. Results As of August 2024, 6 hospitals (involving 9 interventional neurologists) from 4 cities have joined the registry. A total of 560 patients (mean age±standard deviation of 67±13 year; median baseline NIHSS score of 16, IQR 12‐18) treated with thrombectomy are entered in the registry. Occlusion sites were internal carotid artery (n=335), middle cerebral artery M1 or M2 segment (n=306), posterior circulation (n=11), and distal vascular locations (n=11). The mean time mean (minutes±standard deviation) from symptom onset to thrombectomy was 261+/‐148 minutes. Symptomatic intracerebral hemorrhage (≥4 points NIHSS score increase) within 24 hours was observed in 57 subjects. Overall, functional independence at 90 days was observed in 301 (53.7%) of 560 subjects.