The dualistic concept of the human being is a philosophical stance that poses a separation between the mind and the body. It has been widely criticized and revised by recent trends in social sciences, philosophy, and organization studies. Nevertheless, it still tacitly underpins various elements of social organization and sensemaking. The way disability is considered and treated by organizational and institutional policies and practices provides clear examples of the latent dualistic thinking which still persists in this field. In this paper we engage with the dualism present in mainstream understandings and constructions of disability, and propose an approach to overcome this reductionist attitude. This approach refers to and critically revisits Antonio Damasio’s line of argument. We argue that Damasio provides thoughtful insights for a rereading of the medical and social model of disability, and can enrich the debate within disability studies and organization studies, in particular with regards to diversity and inclusion.