Peyronie's disease (PD) is an acquired brotic disorder of the tunica albuginea characterized by penile deformity, pain, and potential sexual dysfunction. This narrative review synthesizes current evidence on the epidemiology, pathogenesis, clinical manifestations, diagnosis, and management of PD. Affecting approximately 5% of men, PD progresses through active and chronic phases, with signicant physical and psychological impacts. Diagnosis relies on clinical evaluation and imaging, particularly ultrasound, to assess plaque characteristics. Non-surgical treatments, such as intralesional collagenase and penile traction therapy, are effective during the active phase, while surgical options, including plication, plaque incision with grafting, and penile prosthesis implantation, are reserved for stable disease with severe deformities. Despite advances, challenges persist in managing residual symptoms and psychological burden. A multidisciplinary approach remains critical for optimizing outcomes and improving quality of life.
