The objective of this research is to answer the research question: Why analyze the economic and financial challenges for micro, small and medium-sized enterprises in the city of León, Guanajuato, Mexico? The type of research is mixed because it is based on grounded theory and contrasts with findings from other national and international research that speak of the economic and financial challenges of MSMEs. For the quantitative analysis, 378 surveys were applied. The results obtained show: That the director of the MIPES has the challenge of properly managing his finances, knowing what he owes and what he has. It is concluded that one of the main economic and financial challenges is not to be financed mainly by its suppliers, but to use bank loans that charge a cheaper rate. Than the price increase made by their suppliers.