This study explores the feminization of poverty and the dynamics of the care economy in rural areas, focusing on the municipality of Génova, Quindío, Colombia. The novelty of this study lies in its analysis of the compounded effects of the COVID-19 pandemic on women’s economic participation and care responsibilities in a rural context, offering insights relevant to Latin America. This study addresses the critical problem of how increased caregiving responsibilities and labor informality during the pandemic have disproportionately impacted economically active women, exacerbating gender inequalities. The objective is to analyze the relationship between the care economy and feminization of poverty, providing policy recommendations for post-pandemic recovery in rural settings. The methodology consisted of a two-stage approach. In the first stage, a probabilistic stratified sampling design was applied using data from the Colombian National Population and Housing Census and the Génova, Quindío, and Colombia Municipal Panel. In the second stage, fieldwork was conducted with a sample of 347 women using the RedCap application for data collection. The results indicate a significant increase in unpaid domestic and caregiving work during the pandemic, particularly for the elderly, disabled, and children. Additionally, labor informality increased, further limiting economic opportunities for women. The key conclusion is that public policies aimed at reducing gender disparities in rural labor markets must prioritize caregiving support and formal employment opportunities for women. These findings suggest that addressing the care economy is crucial for closing gender gaps and fostering equitable economic recovery in rural Latin American areas.