<title>Abstract</title> <underline>Introduction:</underline>Pancreatic cystic neoplasms (PCNs) are a rare group of tumors with a wide range of clinical behaviors, from benign to malignant. With the increasing use of diagnostic imaging, their prevalence has risen, particularly among older patients. <underline>Objective:</underline> To evaluate the clinical course, radiological findings, and surgical outcomes of patients who underwent surgery for PCNs at a tertiary referral center. <underline>Methodology:</underline> This is a retrospective descriptive study of a cohort of patients who underwent surgical intervention for PCNs between March 2010 and November 2023 at the Fundación Santa Fe de Bogotá Hospital. <underline>Results</underline>: A total of 79 patients were included, with a median age of 60 years (IQR 49-69) and females were the most affected (70.9%). At the time of diagnosis, 57% of the patients were asymptomatic. The median size of the cystic lesions was 27 mm, with 36.7% presenting as solitary cysts. The postoperative complication rate was 25.3%, with no in-hospital mortality. The predominant surgical approach was distal pancreatectomy (50.6%), with 44.3% of the cases managed laparoscopically and a low conversion rate to open surgery (2.5%). <underline>Conclusions: </underline>The surgical management of PCNs at this center has proven to be safe and effective, with a low rate of severe complications and no associated mortality.