This paper is an approach to the spiritual experience of the Beguine teachers Mechthild of Magdeburg and Marguerite Porete, from the systematic approach of Spiritual Theology proposed by Jesús Manuel García Gutiérrez. In this reflective exercise, we go through three moments: historical-phenomenological, hermeneutical-theological and practical-mystagogical. The purpose of this research is to synthesize the inner experience of these two medieval women from the parameters of Spiritual Theology, recognizing those characteristics that allow to evidence the mystical and mystagogical mood in them. These women represent a unique expression of female lay spirituality in the Middle Ages, a movement that, although originally spontaneous and without a rigid formal structure, developed into a significant spiritual and social force. Opting for a life of devotion without completely withdrawing from the secular world or submitting to monastic life, these women developed a way of life that combined religious contemplation with social action. They lived in autonomous communities, devoting themselves to prayer, manual labor, and caring for the sick and poor, thus exemplifying a spirituality embodied in the needs and challenges of their time.