Epidermolysis bullosa (EB) is a rare genetic disorder characterized by signicant skin fragility, leading to recurrent blistering and chronic wounds. This narrative review examines the epidemiology, pathogenesis, clinical features, diagnostic approaches, and management strategies, including supportive and experimental therapies. Although no denitive cure exists, advances in gene therapy and novel wound treatments offer promising avenues. A multidisciplinary approach remains crucial for optimizing patient quality of life and long-term prognosis.