This study investigated the impact of intentional activities (IAs) on mental health during the COVID-19 pandemic in Bogotá, Colombia, and the mediating role of family support, social support, and resilience. Results in Study One showed significant predictions of psychological variables by gender, age, and education. Men exhibited higher resilience, while age negatively predicted mental health issues and positively predicted family support, social support, and resilience. In Study Two, IAs predicted family support, social support, and resilience. However, when these mediators were included in predicting mental health, IAs no longer directly predicted it, while family support, social support, and resilience did. In Study Three, an exploratory factor analysis revealed two factors that encompass IAs: creative artistic activities and self-care activities factors. Performing these activities at least once a week positively predicted mental health outcomes, with participants reporting lower mental health issues and higher levels of family support, social support, and resilience. In conclusion, the study emphasizes the importance of engaging in intentional activities during the pandemic for maintaining mental health. Family support, social support, and resilience significantly mediate IAs and mental health outcomes. Encouraging individuals to engage in creative artistic activities and self-care at home may be a cost-effective strategy to promote mental well-being during challenging times.