Abstract Background Psoriasis is a chronic skin disorder characterized by the accelerated proliferation of keratinocytes, which leads to the formation of scaly plaques and a chronic inflammatory response. Vitamin D is an inhibitor of dendritic cells acting as an immune modulator; therefore, vitamin D deficiency could explain the increased incidence of psoriasis for the reduction of anti‐inflammatory activity. Objectives To compare serum 25‐hydroxy vitamin D levels in patients with psoriasis and healthy individuals. Methods A systematic review of the literature and meta‐analysis was performed by searching PubMed, Embase, Cochrane, Lilacs, Ovid and ProQuest databases to find the best available evidence from 2013 to 2024. We also conducted a snowballing literature search to expand the included studies. The methodological quality and risk of bias were assessed through the Newcastle–Ottawa scale. A random effect meta‐analysis model was applied. Results A total of 27 articles were included in the systematic review of these three cross‐sectional studies included in the first meta‐analysis, the synthesized standardized mean difference (SMD) in serum vitamin D between psoriatic arthritis and psoriasis was −0.13 (95% CI [−0.46, 0.20], p = 0.45). The second meta‐analysis included two case controls, the synthesized SMD in serum vitamin D between psoriasis and controls was −0.71 (95% CI [−0.85, −0.57], p = 0.00). Conclusions No difference in vitamin D levels between psoriasis and psoriatic arthritis was found. Psoriasis patients have lower vitamin D levels than the general population. However, further studies are essential to understand how vitamin D levels contribute to the pathogenesis of psoriasis or vice versa and its role in severity.