The term "target fishing" refers to an experimental or computational approach to identify proteins that bind to a particular ligand or molecule of interest. This activity was designed for undergraduate students to explore the search for protein interactions to query molecules. The introductory phase of the project provides students with a general view of key concepts. Subsequently, the participants select a specific case study in which the target fishing technique had been previously applied. Each student analyzes in detail the context of the research, the molecules studied, and the proteins identified as potential targets. The activity seeks not only the practical application of theoretical concepts but also the development of research skills, the critical analysis of results, and participation in collaborative discussions on the relevance of target fishing. Through written reports, oral presentations, and classroom discussions, students will demonstrate their comprehensive understanding of this technique, their ability to contextualize it in real-world studies, and their ability to address issues associated with the application of the method. This project provides an interdisciplinary educational experience that integrates theory and practice, preparing students to understand and effectively apply the target fishing technique, as well as to recognize its limitations.