Aims & Objectives: The utilization of the High-Flow Nasal Cannula (HFNC) in Acute Respiratory Failure (ARF) is on the rise. The Pediatric Intensive Care Unit (PICU) at San José Hospital introduced a rapid HFNC weaning protocol. We assessed its impact on support duration. Methods: A cohort study was conducted through secondary analysis using prospectively collected data from the LARed database. The study included patients aged 1 month to 18 years with acute respiratory failure (ARF) who received high-flow nasal cannula (HFNC) support for at least 24 hours. The study was carried out at the PICU of Sociedad de Cirugia de Bogotá Hospital de San José, where HFNC was employed as non-invasive ventilation (NIV) during two periods: from March 2018 to August 2022 and from October 2022 until the required sample size was reached in July 2023. Support durations pre- and post-protocol implementation were compared. Descriptive statistics and bivariate comparisons were employed, and potential confounding factors were controlled using multivariate negative binomial regression analysis. Results: During the study period, out of 1,200 admissions, 766 received respiratory support via high-flow nasal cannula, removed before discharge. Of these, 555 (72.5%) were pre-protocol, and 211 (27.5%) post-protocol. Median support duration significantly decreased from 62.7 hours (IQR: 36.5-94.9 hours) to 50.1 hours (IQR: 27.5-78.0 hours) (p<0.001). Multivariate analysis revealed a 20.9% reduction in support duration with the new protocol (95% CI 12.1%-28.8%). Conclusions: The rapid HFNC weaning protocol yielded a 20% reduction in support time, implying enhanced efficiency and potential cost savings in pediatric intensive care. Keywords: pediatric intensive care, non-invasive ventilation, High-Flow Nasal Cannula (HFNC), weaning, Respiratory Insufficiency