Aims & Objectives: Pediatric central nervous system tumors stand as the second most common malignant neoplasms in children, with a reported incidence of 1.20 per 100,000 cases, and constitute the first cause of cancer-related mortality, with a reported mortality of 0.59 per 100,000 cases. Even when tumor resection surgery is the standard of care, it might be related to immediate postoperative complications especially in the Intensive Care Unit (ICU). Methods: A longitudinal descriptive study involving pediatric patients hospitalized in the Pediatric Intensive Care Unit (PICU) after CNS tumor resection between 2011 and 2021, excluding patients with extra-institutional surgery or diagnosis and those lacking histopathological reports. Variables were described based on their nature and distribution. Complication incidence neuroinfeccion was calculated with accompanying 95% confidence intervals (CI). This study was approved by the institutional ethics committee. Results: 116 patients were included. Median age was 8 years (4-12), the median time from diagnosis to surgery was 2 days. The most frequent tumor pathology was embryonal tumor (30.2%). Mechanical ventilation was required in 24.1%, with a median extubation time of 3 days. The most common complication were hypophyseal hormones disorders, with an incidence of 16.4%. Neuroinfection occurred in 6,8% patients. Mortality in the PICU was 3.4% (CI95: 1.1%-9.1%); the median length of stay was 4 days. Conclusions: This study reports post-surgery complications at PICU for CNS tumors. Disorders in pituitary hormones neuroinfection and seizures were the most common complications, similar to literature. Therefore, strict monitoring is necessary to prevent long-term morbidity burden and reduce health care costs. Keywords: CNS tumors, brain tumors, postop complications