Aims & Objectives: One of the most common complications in cardiovascular surgery is the presence of vasoplegic syndrome. This is a postoperative condition that includes low vascular resistance, associated with a normal cardiac index, that does not respond to IV fluids and requires high doses of vasopressors. The objective of the current study is to determine the main risk factors for the pediatric population. Methods: This retrospective observational study included pediatric patients between 2011 and 2021 at a single hospital. Demographic, preoperative, intraoperative and postoperative variables were taken into account. Univariate analysis was performed for all variables and multiple logistic regression was carried in significant variables. Results: A total of 185 patients were included, from which 64 developed vasoplegic syndrome, resulting in an incidence of 34,59%. In the vasoplegia group patients had lower mean age and weight, there was a higher rate of preoperative shock, higher rate of respiratory infections and longer surgical times. When evaluating the outcomes, the vasoplegia group had a higher pediatric intensive care unit (PICU) and hospital stay, as well as prolonged requirement of vasopressors and higher presence of postoperative fever. Conclusions: Patients with lower age and weight, previous shock, respiratory tract infections and higher surgical times were at a higher risk of vasoplegia. There need to be more studies regarding the pediatric population to determine specific interventions for these patients. Keywords: Vasoplegia, vasoplegic syndrome, congenital heart disease, Pediatric, cardiovascular surgery