Epidendrum clinidiodontum is described and illustrated as a new species from the eastern slope of the Eastern Andean Cordillera from Caquetá and Cundinamarca, Colombia. The species belongs to the informal Albertii group and Ellipsophyllum subgroup and is vegetatively similar to Epidendrum hygrohylephilum but differs in having the lip pentagonal, base slightly cordate and margin crenate, the clinandrium-hood bidentate, and the callus laminar.