Aims & Objectives: To evaluate the clinical behavior of episodes of respiratory rhinovirus infection compared to infection by other viruses, diagnosed by FilmArray®, in pediatric patients admitted to a high-complexity hospital in Bogotá, between January 2014 and December 2022, depending on the moment epidemiological (COVID19 pre-pandemic, during isolation and post-isolation). Methods: Through a retrospective analytical observational cohort study, we analyzed pediatric patients between 1 month and 18 years old who were hospitalized between January 2014 and December 2022 with a diagnosis of acute respiratory infection. Through descriptive statistics we calculated the distribution of infection by rhinovirus and other viral agents, we described the characteristics of the population studied for each of the three epidemiological moments and we established the causal association between each etiological agent and outcomes using a log binomial model. Results: The main isolation was rhinovirus, with an increase in its prevalence during the pandemic. There was a higher percentage of bacterial coinfection in pre-pandemic, showing greater coinfection for rhinovirus as a single isolate vs. polyviral infection, with RR 1.578, CI (1.067-2.334). Obstructive involvement for rhinovirus predominated in all periods, with a greater number of admissions to the PICU for this agent during the pandemic, 54.5% RR 0.943 (CI 0.645-1.378). The predominant respiratory support in case of failure was a high-flow cannula and there was no significant association between risk factors and severity. Conclusions: Rhinovirus infection was more prevalent during the three epidemiological periods, being significantly associated with greater bacterial coinfection but not with severity, evidencing an increase in polyviral infections in post-isolation. Keywords: Respiratory infection, film array, rhinovirus, pandemic