Aims & Objectives: Prolonged endotracheal intubation (PETI) and extubation failure (EF) has been associated with increased risk of pneumonia, hospital stay and mortality. The aim of this study was to determine the factors associated with PETI in a pediatric cardiovascular intensive care unit (ICU) in Bogotá, Colombia. Methods: Retrospective study, from 2010 to 2022, we collected data (Fundación cardioinfantil, Colombia). Analysis of variance (ANOVA) was used to compare means of lactate in the first hour, 24hrs later and 48hrs later, Wernosvsky score in the first hour, 24hrs later and 48hrs later in comparison with PETI. A logistic regression model (LRM) was used to analyze variables as potential predictors of prolonged orotracheal intubation or prolonged ICU stay [AUC: 0.925; Hosmer and Lemeshow goodness of fit (GOF) p>0.001; GOF p>0.001]. A value of p < 0.05 was established as statistically significant in all tests. R was used as statistical software version 4.3.1. Results: 5796 hospitalizations were recorded in the postoperative cardiovascular ICU 435 (7.51%) had PETI.There were no significant statistical differences in prolonged ETI or EF by age group or sex (p>0.005).Within the prolonged ETI group, 10.34% were classified as EF.In ANOVA analysis all variables were statistically significant with very low p values(p<0.001) indicating that patients with PETI tend to have associated changes in lactate levels and Wernosvsky scores.In LRM, prolonged ICU stay(OR:5.55;CI95%:2.52-12.43;p<0.005), open surgery(OR:25.8 CI:11.32-62.8;p<0.005), high RACHS value (≥3; OR: 1.87 CI: 0.79-4.35;p<0.005), complications such as Renal(OR:4.84;95%CI:1.72-14.65;p 0.0002),Infectious(OR:2.57;95%CI:0.99-6.65;p:0.010) and cardiac (OR:3.35;95%CI:1.58-7.40;p<0.005)were associated as predictors of PETI. Conclusions: Associated factors with PETI were identified, providing clinical utility fordecision-making. Keywords: hospital mortality, tracheal extubation, intensive care, Cardiac surgery