Chronic low back pain is one of the leading causes of disability worldwide. This study evaluated the effects of supervised exercise therapy on physical function and quality of life in patients with chronic low back pain. A randomized clinical trial was conducted with 100 participants divided into two groups: an experimental group that received supervised exercise therapy for 12 weeks and a control group that received standard treatment. The results showed significant improvements in physical function and quality of life in the experimental group compared to the control group. These findings suggest that supervised exercise therapy is an effective intervention to improve quality of life in patients with chronic low back pain.